2013 Volume 50 Issue 6 Pages 410-415
Improvement of flowability and dissolution property of particles was conducted by a dry surface modification using a novel shear mixer with a super high speed chopper (SPM mixer). Corn starch and ibuprofen were treated with silica under various rotation speeds and operation time. The flowability was evaluated by an angle of repose and dissolution property was evaluated by a dissolution test according to the Japanese Pharmacopoeia.
It was found that composite particles with good flowability were obtained within 1 minute treatment time. And it was implied that the faster rotation speed of chopper resulted in the shorter treatment time.
In the SPM mixer, surface modification and grinding were progressed simultaneously. Within 1 minute treat time, the particle size was smaller and dissolution velocity was faster by an increase of rotation speed of chopper. And composite particles with superior flowability obtained.
