Development of Oral Formulation Technology for Nucleic Acid Drug by Using PLGA Nanoparticles as DDS Carriers

Yusuke Tsukada; Hiroyuki Tsujimoto; Hajime Watanabe; Takayuki Sugimoto; Osami Nakano; Hirofumi Makino; Hiromitsu Yamamoto; Ryuichi Morishita

doi:10.4164/sptj.50.513

Technical Note

Development of Oral Formulation Technology for Nucleic Acid Drug by Using PLGA Nanoparticles as DDS Carriers

Yusuke Tsukada, Hiroyuki Tsujimoto, Hajime Watanabe, Takayuki Sugimoto, Osami Nakano, Hirofumi Makino, Hiromitsu Yamamoto, Ryuichi Morishita

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Keywords: PLGA nanoparticle, Drug Delivery System, Nucleic acid, NF-κB decoy, Tablet, Seamless capsule

JOURNAL RESTRICTED ACCESS

2013 Volume 50 Issue 7 Pages 513-518

DOI https://doi.org/10.4164/sptj.50.513

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Abstract

PLGA nanoparticles (NPs) have possibility to become the useful oral DDS for nucleic acid drug. The nanocomposite powder that PLGA NPs dispersed in matrix of excipient were prepared to make two kinds of solid dosage forms such as the enteric tablet and seamless capsule containing the NF-κB decoy nucleic acid loaded PLGA NPs for human oral administration model. These two solid dosage forms proposed here showed to be high applicable for the oral DDS.

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