Abstract
In the tabletting process, we occasionally face tabletting troubles which are obstacle to assure quality of tablet. Generally, medicine including tablet was required high level of quality, so we have investigated to prevent tabletting troubles from taking place from various aspects. In this study, we focused on surface affinity between punches for tabletting and formulations, cohesion of formulations. Distance of surface free energy was used as the index of surface affinity. Porosity was used as the index of cohesion. When polar component of surface free energy of punches was low, adhesion of the formulations to punch was controlled by surface affinity. When polar component of punches was high, adhesion to punch was controlled by cohesion of formulations. Factors affecting the adhesion were different depending on the system.
