Preparation of Co-ground Mixture of Erythritol and Micronized Crospovidone Using a Ball Mill for Orally Disintegrating Tablets

Abstract

The purpose of this study was to prepare a co-ground mixture of erythritol and micronized crospovidone (M-CPVP) to prepare the orally disintegrating tablets (ODTs) by directly compressing. The co-ground mixture was prepared by ball milling. Several processing time for ball mill and the different ratio of M-CPVP / erythritol were tested to determine the appropriate agglomerates for designing the ODTs. The ODTs containing co-ground M-CPVP/erythritol mixture showed rapid disintegration (<30s) and adequate hardness of the tablets (tensile strength>1.0MPa). On the other hand, the powder mixture without this co-processing had poor compactibility, and the tableting trouble such as capping was observed. Heckel analysis revealed that the plasticity of powder bed containing co-ground mixture was higher than the powder mixture without co-processing. We could also demonstrate that ODTs containing ethenzamide, as an active ingredient, could be prepared using the co-ground M-CPVP/erythritol mixture.