The Formulation Characterization by Terahertz Spectroscopy

Abstract

Terahertz time-domain spectroscopy (THz-TDS) is a technology which is expected as a new PAT tool in the pharmaceutical field. It is safe because energy is low, and it can be used to analyze the state of material inside without breaking. We conducted two experiments using THz-TDS. One was a component analysis by transmittance spectrum, and the other was coating thickness measurement. These experiments were qualitatively assessed which components of the mixed granules, and also estimated the thickness of the coating. These results showed the potentially can be used THz-TDS as PAT tool.