2016 Volume 53 Issue 9 Pages 591-597
In this study, a novel continuous manufacturing system composed of mixing, kneading, granulation, and drying has been developed and its performance was evaluated experimentally.
First of all, agitation torque during kneading process was continuously measured using different kinds of powder samples and binder liquid addition ratios, and state of liquid/powder mixture was analyzed. Residence time and hold-up of wet kneaded mass were also measured during the kneading process. Based on the results obtained, the optimum operating regions of screw agitation speed and powder feed rate were determined. Orally rapidly disintegrating tablets were then prepared by the granules made by the continuous system and properties of tablets were evaluated. It was found that the optimum binder addition rate could produce orally rapidly disintegrating tablets with favorable properties.
