Journal of the Society of Powder Technology, Japan
Online ISSN : 1883-7239
Print ISSN : 0386-6157
ISSN-L : 0386-6157
Review
Design of Cell-Specific Liposomal DDS by Surface Modification of Functional Polymers
Eiji Yuba
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2018 Volume 55 Issue 7 Pages 389-396

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Abstract

Surface modification of functional polymers onto liposomes is effective strategy to obtain functional liposomes that release drugs at target site or intracellular compartments. Here, design of pH-sensitive liposomes for cell-specific intracellular drug delivery was summarized. Liposomes modified with hyaluronic acid derivatives exhibited selective anticancer drug delivery to CD44-expressing cancer cells. Furthermore, liposomes modified with curdlan derivatives were efficiently recognized by dendritic cells, leading to efficient antigen delivery, activation of dendritic cell and induction of antitumor immunity on tumor-bearing mice. Therefore, functional polymer-modified liposomes are promising for cell-selective cancer chemotherapeutic system or immunotherapeutic systems.

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© 2018 The Society of Powder Technology, Japan
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