2020 Volume 57 Issue 11 Pages 577-587
The purpose of this study is to evaluate the effect of tableting speed on the compression behavior of pharmaceutical powders using an R&D rotary tablet press. Cilostazol, probucol and ibuprofen were selected as model drugs, and they were mixed at a mass concentration of 20% into two base formulations composed of different excipients. The tablets were prepared at two levels of turret rotation speeds of 20 rpm and 60 rpm, and the physical properties of the tablets were evaluated. As a result, placebo tablets and cilostazol tablets had no effect on the tableting speed. However, the compressibility of probucol and ibuprofen tablets decreased and the capping tendency was observed, although the compactibility was not affected. The strain rate sensitivity (SRS) index was obtained from an out-of-die Heckel analysis, which was used to quantitatively evaluate the effect of tableting speed on the compressibility. It was found that the R&D rotary tablet press was possible to evaluate the compressibility and capping tendency by the SRS index.
