Effect of Mannitol Addition on Dissolution Improvement of Solid Dispersion

Abstract

Solid dispersion is a common useful technique which makes a crystal drug into amorphous. It improves the dissolution of the insoluble drug by using a rise in solubility, to increase the gastrointestinal tract absorption. In this study, dissolution characteristics of solid dispersion were improved by adding mannitol to the solid dispersion. The effect of mannitol addition to the solid dispersion formulation including PVP-K30 on the dissolution property was investigated. A large difference was observed between two manufacturing methods, a solvent distillation by an evaporator and a spray drying. The different effect of the mannitol addition appeared in the influence of the particle size of solid dispersion particles, although the composition of solid dispersion manufactured by both methods was the same.