2023 Volume 60 Issue 11 Pages 663-668
The effect of the binder dispersion and mixing state on the strength of compression molded tablet was experimentally investigated. In order to clarify the effect, the sample powders were prepared by a model mixing operation in which the ratio of binder-mixed and unmixed samples was controlled with keeping the ratio of the binder mass to powder mass. The mixing state was quantitatively evaluated by Morishita’s dispersion index, which was proposed for representing the aggregation state of a group of individuals in ecology field. The strength of compression molded tablet prepared by the model mixing operation was correlated with Morishita’s dispersion index. In addition, the strength of compression molded tablet prepared by mechanical mixing was also expressed by the same correlation line obtained by the model mixing experiments. Therefore, it is considered that the mixing state of the polymer binder, which affects the strength of the compacts, can be evaluated by Morishita’s dispersion index.
