Abstract
Binary mixtures of sulfisomidine and lactose particles were suspended in chloroform and were agglomerated with buffered sodium phosphate solutions (pH7.4). The agglomerate particles at 1.5min residence time were fractionated by sieves at six levels according to the particle size. The content ratio of sulfisomidine of the each fraction to the original feed powder was determined. The significant variance of the content ratio with the particle size of the agglomerates was found, which strongly depended on the particle size of lactose and the mixing ratio of sulfisomidine.
With increasing the particle size of lactose and decreasing the mixing ratio of sulfisomidine, the content ratio in the agglomerate with over size (+12mesh) decreased, which indicates that the larger lactose particles are included more in the agglomerate with increasing the particle number of lactose in the system. The content variation disap Peared gradually when the agglomerate particles growing in the course of agitating the suspension. This suggests that the more preferential adhesion may occure between the larger lactose and sulfisomidine particles, leading to the formation of the agglomerate enriched with lactose.
