A Mathematical Simulation of Controlled Release from Matrix-type Drug Delivery Systems

Abstract

A general mathematical model for predicting the drug release from various shapes of matrix-type drug delivery systems was solved using a method-of-lines procedure. The effects of the device shape, the diffusion boundary layer and the internal structure (porosity) on the rate of drug release were analyzed numerically. The present study is of practical significance for establishing an optimum design method for matrix-type drug delivery systems.