Improvement in Dissolution Property of Poorly Water-soluble Drugs by Using Mechanofusion System

Yoshiro Nagai; Hiromitsu Yamamoto; Hirofumi Takeuchi

doi:10.4164/sptj.43.640

Journal of the Society of Powder Technology, Japan

Online ISSN : 1883-7239
Print ISSN : 0386-6157
ISSN-L : 0386-6157

Improvement in Dissolution Property of Poorly Water-soluble Drugs by Using Mechanofusion System

Yoshiro Nagai, Hiromitsu Yamamoto, Hirofumi Takeuchi

Author information

Keywords: Poorly water-soluble drug, Ball mill, Mechanofusion system, Composite particle, Dissolution rate

JOURNAL FREE ACCESS

2006 Volume 43 Issue 9 Pages 640-647

DOI https://doi.org/10.4164/sptj.43.640

Details

Abstract

The dissolution property of poorly water-soluble drug, indomethacin, was improved by using a ball mill or a mechanofusion device. Co-grinded samples with indomethacin loading higher than 80% were prepared by mixing it with several additives. The highest dissolution rate of indomethacin was attained for the drug dispersion prepared with magnesium aluminomethasilicate (Neusilin) and additives such as PEG6000, sorbitol, mannitol.

Content from these authors

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!