2008 Volume 45 Issue 12 Pages 812-818
Lactobacilli (streptococcus faecalis WB2000) are effective in controlling plaque, in preventing dental caries and periodontal disease and in preventing halitosis.
In this study, pharmaceutical thin films, with live lactobacilli, were developed and examined as a dosage form that disintegrates rapidly and stays in the oral cavity. Four dosage forms were designed. Films were formed in a single layer, (A) and (B), and in two layers, (C) and (D). All films showed rapid disintegration and satisfactory mechanical strength. Dosage form (D) which consists of an active ingredient layer and a base layer without a plasticizer of glycerin gave the most excellent stability in preservation among the four. Lactobacilli formulated in (D) showed the same growth tendency as the powder lactobacilli. Pharmaceutical solid dosage film (D) as a new Lactic acid bacteria preparation could be designed.
