The purpose of this study is to analyze the potent influence on depression tendency caused by techno-centered tendency. We made a comprehensive study of stress, techno-centered tendency, depression tendency, loneliness and the purpose and the tool of the internet use. It was investigated and analyzed by the structural equation model based on questionnaire surveys of university students in the information sciences. The result verified that a rise in the techno-centered tendency causes the increase in the depression tendency. We also proved that the influence depend on the purpose of the Internet use. Moreover, it was shown that the adverse effect of the techno-dependency tendency was more than twice the stress effect. As a preventive measure against the depression tendency in the information society, we concluded that it is essential to prevent techno-centered and refrain from using the internet for escaping from reality.