Total synthesis of antibiotic thiazostatin and watasemycin

Abstract

Watasemycin is a novel antibiotic having activity against Gram-positive and negative bacteria, yeast, etc. isolated from actinomycete (Streptomyces sp.) TP-A0597 in deep sea water of Toyama Bay. Its structure is characteristic of a continuous thiazoline ring and thiazolidine skeleton. In this paper, we report the fast synthesis of Thiazostatin and Watasemycin, which are key to the construction of thiazoline ring and condensation of thiazolidine ring from aldehyde derivative via condensation reaction of salicylic acid derivative and corresponding amino acid.