Relationships between Astograph and MostGraph

Abstract

Bronchial hyperresponsiveness is useful as a marker for diagnosis and management of bronchial asthma. We investigated bronchial hyperresponsiveness using the Astograph method. Furthermore, in recent years, MostGraph has attracted increased attention as a method for analyzing respiratory resistance using oscillometry. Therefore, we compared the two methods and investigated the relationship. We recruited 117 individuals whose data were measured by MostGraph and Astograph from a previous study. The levels of Rrs were significantly correlated with each MostGraph index. SGrs/Grscont showed a weak correlation with indicators other than the Ax (R5: r=0.199, p=0.019, R20: r=0.220, p=0.008, X5: r=−0.179, p=0.037, Fres: r=0.195, p=0.021) . The levels of logPD_35Grs, logDmin, and logPD_15Grs exhibited weak correlations with X ₅, Fres, and Ax (logPD_35Grs: X5: r=0.201, p=0.00189, Fres: r=− 0.210, p=0.013, AX: r=−0.169, p=0.049, logDmin: X5: r=0237, p=0.0054, Fres: r=−0.213, p= 0.012, AX: r=−0.177, p=0.038, logPD_15Grs: X5: r=0.236, p=0.0056, Fres: r=−0.215, p=0.011, AX: r=−0.174, p=0.043) . The FEV₁ and MostGraph indicators were significantly correlated, but no relationship was shown with the FeNO. In conclusion, evaluating the results of airway hyperresponsiveness tests using the FeNO, FEV₁, and MostGraph indicators is difficult, but the reactance component may reflect bronchial sensitivity and hyperresponsiveness.