2018 年 9 巻 1 号 p. 7-14
Transplanting the ovaries of young mice into menopausal mice has been shown to extend their lifespan, suggesting that the reproductive organs may play an important role in combating aging. Preventing skin aging is an extremely important matter with respect to maintaining quality of life, but little basic research has been conducted to examine this issue. The effects of treatment with cryopreserved ovarian tissue, tissue hormone therapy (THT), and hormone replacement therapy on inhibiting skin aging were investigated in experimental animals. The effects on skin elasticity (R7) and body weight changes in 6-week-old mice resulting from the transplantation of cryopreserved ovarian tissue were evaluated, as were the effects on skin of estrogen administration after bilateral oophorectomy or transplantation. After the ovaries of 6-week-old mice were removed, the mice increased in weight over time. Their R7 temporarily decreased significantly to 3-week after oophorectomy, and subsequently improved. Mice were allocated into several different groups, including one that was given estrogen continuously for three weeks from immediately after oophorectomy and another that underwent transplantation of thawed ovarian tissue on the day after oophorectomy. While there was no difference of R7 between the hormone replaced groups and the sham surgery group, it was significantly lower in the non-replaced groups and the transplantation group than in the sham surgery group on day 14 and 18. R7 was still significantly lower on day 21 in the non-replaced group, but not in the transplantation group.R7 on day 21 in the transplantation group was significantly improved from that on day 18. These results suggest that THT and hormone replacement therapy (HRT) might be equally effective. If techniques for THT using cryopreserved ovaries to maintain the blood estrogen concentration above a specific level can be established, this might help prevent or improve the deterioration of skin appearance in young women who require oophorectomy due to gynecological disease and also in childhood, adolescent, and young adult cancer patients.
