A case of adult T-cell leukemia/lymphoma in the oral cavity as an early symptom

Takamasa SHIROZU; Hiroyuki KINOSHITA Hiroyuki KINOSHITA; Noriko MATSUZAWA Noriko MATSUZAWA; Kensuke NAGANAWA Kensuke NAGANAWA; Shigeaki YAGI Shigeaki YAGI; Toru NAGAO

doi:10.11277/stomatology.58.20

CASE REPORTS

A case of adult T-cell leukemia/lymphoma in the oral cavity as an early symptom

Takamasa SHIROZU, Hiroyuki KINOSHITA Hiroyuki KINOSHITA, Noriko MATSUZAWA Noriko MATSUZAWA, Kensuke NAGANAWA Kensuke NAGANAWA, Shigeaki YAGI Shigeaki YAGI, Toru NAGAO

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Keywords: Adult T-cell leukemia/lymphoma (ATLL), Lymphoma type, Oral region, Maxillary bone, Cervical lymph node

JOURNAL FREE ACCESS

2009 Volume 58 Issue 1 Pages 20-26

DOI https://doi.org/10.11277/stomatology.58.20

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Abstract

Adult T-cell leukemia/lymphoma (ATLL) is induced by human T-lymphotropic virus type 1 (HTLV-1) infection. We report a case of ATLL in the oral cavity as an early symptom.
A 58-year-old female was referred to our hospital because of right upper gingival pain. Imaging study revealed a swelling of multiple cervical lymph nodes and a mass lesion destroying the right maxillary bone. Biopsy from a cervical lymph node was done and the pathological diagnosis was T-cell lymphoma. Serologically, anti-HTLV-1 antibody was positive. Southern blot analysis used by the lymphocyte of peripheral blood showed monoclonal proliferation of HTLV-1 provirus DNA. We finally made the diagnosis of ATLL (lymphoma type). She was treated by systematic chemotherapy, and recovered well with no evidence of recurrence for over 2 years.

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