2014 Volume 63 Issue 2 Pages 226-232
This report describes an unusual case of verruciform xanthoma (VX) occurring in a patient with multiple stomatitis. A 43-year-old woman visited our hospital on May X, 2012, because of a white lesion on the left side of the tongue. She had been suffering from multiple stomatitis for 6 years. She had experienced burning sensations during mastication on her oral mucosa and so had been treated with oral hygiene products at the time of symptom onset. Her dentist noticed the white lesion in May 2012, and referred her to our hospital. Intra-oral examination revealed a relatively well-circumscribed, slightly raised lesion. The lesion was rough granular with a white surface, measuring 8 × 6mm in size, without induration around the lesion. A benign tumor was suspected, and an excisional biopsy was performed under local anesthesia on May Y. There has been no evidence of recurrence. Histopathological examination revealed a papillary proliferation of stratified squamous epithelium associated with hyperparakeratosis and uniformly elongated rete pegs. The connective tissue papillae were largely filled with foamy cells, which were positive for CD 68, and negative for S-100 protein. Based on these findings, a final diagnosis of VX was made.
