1989 Volume 38 Issue 4 Pages 831-839
A (phenylephrine injection) group, light microscopically, morphological changes of granular convoluted tubular (GCT) cells were characterized by duct dilation and degranulation, and GCT cells had few secretory granules (SGs) 120 minutes after phenylephrine injection.
Recovery of SGs had already begun at 12 hr and GCT cells had been full of SGs, but had been not completely finished at 24 hr.
Electron microscopically morphorogical changes of GCT cells were characterized by small SGs near apical cytoplasm and secretory materials in the lumen, but were not observed in any other sites. These results indicated that synthetic site of mEGF couldn't be detected in the process of forming SGs.
There were three kinds of secretory methods to duct of mEGF-eruptocrine secretion, holocrine secretion, and their mixture. In B (isoproterenol injection) and C (pilocarpine injection) groups, morphological changes of GCT cells were not predominantly observed, but those of acinar cells were characterized by duct dilation and vacuolous degeneration.
