To investigate how diabetes affects the progression of maxillofacial infection, viable bacterial cell counts, wet weight of exudate, and histopathological changes in an experimental buccal infection were examined for 48 hours after inoculation ofStreptococcus pyogenesS-8 into the cavity of carageenin-induced buccal abscess in diabetic rats induced by streptozotosin. Viable bacterial cell counts in diabetic rats were increasing after 36 hours following inoculation ofS. pyogenesS-8, and there were significant differences at 36 and 48 hours between diabetic rats and the control group. Weight of the exudate in abscesses in diabetic rats was significantly higher compared with the control group at 48 hours, and also in this stage, histopathological examinations in diabetic rats revealed more predominant infiltration of inflammatory cells than in the control, which indicates higher vascular permeability in diabetic rats. These results suggest that some factors, in addition to suppression of chemotactic activity of leukocytes, may be related to the bacterial growth in diabetic rats of this model.
