2002 Volume 51 Issue 4 Pages 273-276
Verruciform xanthoma in the oral mucosa is an uncommon benign lesion characterized histopathologically by papillary or verrucous proliferation of squamous epithelium and numerous foam cells. We present a case of a 60-year-old female with verruciform xanthoma at the floor of the mouth. The lesion was clinically diagnosed as a papilloma. Histopathological findings showed a papillary proliferation of stratified squamous epithelium in association with parakeratosis and relatively uniform elongated rete pegs. Numerous foam cells were located in the connective tissue papillae between the rete pegs. Immunohistochemically, the foamy cells were positive to lysozyme, vimentin, CD-68, α-1 antitrypsin and Desmin, but negative to S-100 protein. These findings support the concept that the foam cells are derived from a monocytemacrophage lineage.
