日本口腔科学会雑誌
Online ISSN : 2185-0461
Print ISSN : 0029-0297
ISSN-L : 0029-0297
舌に症状を伴ったvon Recklinghausen病の1例
遺伝子検索および文献的考察
君 賢司
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ジャーナル フリー

2004 年 53 巻 2 号 p. 91-97

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Von Recklinghausen's disease is a syndrome defined by the presence of café-au-lait spots and multiple benign neurofibromas. We report a 12-year-old boy with involvement of the tongue associated with von Recklinghausen's disease. The patient presented with a chief complaint of a mass of the tongue. Clinical examination showed multiple brown pigmented spots of the skin and a painless mass in the left side of the tongue. Clinical diagnosis was a tongue tumor associated with von Recklinghausen's disease, and the tumor was surgically excised. Histopathologically, the specimen was diagnosed as plexiform neurofibroma. No gene abnormality can be found by G-banded analysis and fluorescence in situ hybridization (FISH) analysis. The patient showed no evidence of recurrence during the next 1 year, but careful follow-up is needed because the malignant tumor associated with von Recklinghausen's disease might occur in the oral region.

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