唾液腺腫瘍56例の臨床・病理組織学的検討

抄録

Fifty-six cases of salivary gland tumors histopathologically diagnosed at the Department of Dentistry and Oral Surgery, School of Medicine, Keio University from Janu ary 1998 to December 2005 were reviewed and clinically analyzed. The results were as follows:
1. They were composed of 67.9% benign tumors and 32.1% malignant tumors
2. They were 30 males (53.6%) and 26 females (46.4%), and the male to female ratio was 1. 2: 1.
3. Their mean age was 51.9 years old with a peak incidence in the fifth to sixth decade of life.
4. Swelling was the most common symptom presented. There was pain and ulcer in addition to swelling in malignant tumors.
5. Parotid gland tumors were most common in major salivary glands and palatal gland tumors were most common in minor salivary glands.
6. Pleomorphic adenoma was most common in benign tumors. Of malignant tumors, 8 were adenocystic carcinoma, 5 mucoepidermoid carcinoma, 3 adenocarcinoma, one carcinoma in pleomorphic adenoma and one acinic cell carcinoma.
7. Surgical treatment was performed for all benign tumors and 88.9% of malignant tumors. In malignant tumors radiotherapy and/or chemotherapy were used concomitantly.
8. Recurrence rate of benign tumors was 5.6% and that of malignant tumors was 27.8%. The cumulative survival rate for all malignant cases was 86.5% at 5 years and at 10 years.
9. We report rare cases of carcinoma in pleomorphic adenoma in the palate that developed from benign pleomorphic adenoma and familial pleomorphic adenoma.