The novel hydroxyapatite ceramics, NEOBONE®, has a unique porous structure with fully opened interpore connections. This structure has the advantage that host tissues promptly grow into the pores. Clinical usage of NEOBONE® has been reported in the orthopedic field, but not in the oral and maxillofacial field. Granulated powder of NEOBONE® was filled into bone defects in 16 cases consisting of 15 bone cysts and one benign tumor. We followed up all the cases for more than six months. Adverse events were not observed in any of the cases.X-ray findings revealed that the opacity between NEOBONE® and bone increased as a result of bone regeneration. NEOBONE® was shown to be easy to use and harmless for the surrounding tissue. In conclusion, NEOBONE® is a useful bone substitute to fill defects of bone in the oral area.
