ジエチルパーオキシド誘導体—そのモズク中毒原因物質としての可能性

伏谷 伸宏; 橋本 周久

doi:10.2331/suisan.47.1059

Diethyl Peroxides Probably Responsible for Mozuku Poisoning

Nobuhiro FUSETANI, Kanehisa HASHIMOTO

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JOURNAL FREE ACCESS

1981 Volume 47 Issue 8 Pages 1059-1063

DOI https://doi.org/10.2331/suisan.47.1059

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Published: August 25, 1981 Received: March 31, 1981 Available on J-STAGE: February 29, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: February 29, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Brown marine algae of the families Chordariaceae and Nemacystaceae have sporadically caused human intoxications known as mozuku poisoning. In the present study, some of these seaweeds were extracted and tested for toxicith in mice. The fat soluble fractions prepared from Sphaerotrichia divaricata and Cladosiphon okamuranus were found to be toxic. There toxic perooxides have been isolated from the former alga by using mainly chromatographic techniques. The principal toxin, α, α′-dihydroxy diethyl peroxide, has been synthesized to confirm its structure and toxicity. It was suggested that these toxins are most likely responsible for mozuku poisoning.
These algae seem to become toxic at a particular stage of their life cycle. It was also demonstrated that the toxins were quite labile in an algal body and were generated only when the body was heated with water. Similar peroxides have been found in the brown alga Analipus japonicus and also in the red alga Gracilariopsis chorda.
Right : Brown marine algae of the families Chordariaceae and Nemacystaceae have sporadically caused human intoxications known as mozuku poisoning. In the present study, some of these seaweeds were extracted and tested for toxicith in mice. The fat soluble fractions prepared from Sphaerotrichia divaricata and Cladosiphon okamuranus were found to be toxic. There toxic perooxides have been isolated from the former alga by using mainly chromatographic techniques. The principal toxin, α, α'-dihydroxy diethyl peroxide, has been synthesized to confirm its structure and toxicity. It was suggested that these toxins are most likely responsible for mozuku poisoning.
These algae seem to become toxic at a particular stage of their life cycle. It was also demonstrated that the toxins were quite labile in an algal body and were generated only when the body was heated with water. Similar peroxides have been found in the brown alga Analipus japonicus and also in the red alga Gracilariopsis chorda.

Date of correction: February 29, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Brown marine algae of the families Chordariaceae and Nemacystaceae have sporadically caused human intoxications known as mozuku poisoning. In the present study, some of these seaweeds were extracted and tested for toxicith in mice. The fat soluble fractions prepared from Sphaerotrichia divaricata and Cladosiphon okamuranus were found to be toxic. There toxic perooxides have been isolated from the former alga by using mainly chromatographic techniques. The principal toxin, α, α'-dihydroxy diethyl peroxide, has been synthesized to confirm its structure and toxicity. It was suggested that these toxins are most likely responsible for mozuku poisoning.
These algae seem to become toxic at a particular stage of their life cycle. It was also demonstrated that the toxins were quite labile in an algal body and were generated only when the body was heated with water. Similar peroxides have been found in the brown alga Analipus japonicus and also in the red alga Gracilariopsis chorda.

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