Effects of Bath Salinity and Number of Fish on the Uptake of Oxolinic Acid by Ayu

Abstract

Effects of artificial sea salts and two types of salt (Gen-En and Nami-En) in the bath water and the number of fish on the uptake of oxolinic acid by Ayu Plecoglossus altivelis were examined.
The data were analyzed according to the one-compartment model in which the accumulation process is characterized by two pharmacokinetic parameters, the clearance constant and volume of distribution, and the volume of distribution reflects the capacity of accumulation. The volume of distribution in ayu exposed to oxolinic acid in fresh water and 0.85% salt (either Gen-En or Nami-En) water were similar and about 5 times higher than those obtained in 12.5% diluted arti-ficial sea water.
The number of ayu had no effect on the uptake of oxolinic acid.