Online ISSN : 1349-998X
Print ISSN : 0021-5392
Antitumour Activity of Polysaccharides and Lipids from Marine Algae
Hiroyuki NodaHideomi AmanoKoichi ArashimaShinziro HashimotoKazutosi Nisizawa
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1989 Volume 55 Issue 7 Pages 1265-1271


For elucidation of the entity of antitumour activity of marine algae, 17 kinds of polysaccharide preparations of seaweed origin and 24 kinds of lipid fractions extracted from various seaweeds were selected as experimental material in addition to pectin. Mice implanted with Ehrlich carcinoma and Meth A fibrosarcoma were used as assay animal. Appreciable inhibition of tumour growth was found for fucoidan preparations form Undaria pinnatifida and Sargassum ringgoldianum, carrageenans and porphyran, being 51.7-54.5, 78.1, 40.1-54.0, and 45.3-58.4 %, respectively. The antitumour activities of lipid fractions against Meth A fibrosarcoma were found to be 36.1-47.1% with all the 3 fractions from S. ringgoldianum, and those of glycolipid and phospholipid fractions from L. angustata were as high as 45.9 and 58.0%, the latter of which was obtained from nearly 1/6 amount of injection. Phospholipid fraction from P. yezoensis showed very high activity such as 64.0% which was the value at the injection of nearly the same amounts as above, and it was the highest value among all the fractions tested in this work.

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