Familial pancreatic cancer registry and surveillance study for the early detection of pancreatic cancer

Abstract

A history of Familial pancreatic cancer and pathogenic variants of certain germline genes (hereditary pancreatic cancer syndrome) are known risk factors for the development of pancreatic cancer. For individuals at high risk of developing pancreatic cancer, surveillance for early diagnosis of pancreatic cancer may lead to early detection of the disease, but it is not yet widely accepted in clinical practice. However, clinical demand for the early detection of pancreatic cancer is increasing, and the Japanese Pancreatic Association has been operating a familial pancreatic cancer registry system since 2014, and has reported on the "Surveillance Methods for the Familial High-Risk Group of Pancreatic Cancer (Expert Consensus)" as an expert opinion. In addition, the DIAMOND study, a prospective study aimed at establishing a surveillance method for early detection of pancreatic cancer in families with familial pancreatic cancer or hereditary tumor syndrome, is also ongoing. These efforts are expected to contribute to the improvement of pancreatic cancer prognosis.