抄録
Parkinson's disease (PD) is characterized by the presence of abnormal involuntary movements. One of the symptoms is a resting tremor at a frequency of between 3 and 6Hz. The oscillatory network producing the tremor is located in the brain; however, the origin of the tremor has not been fully determined. In the present study we examined EEG and EMG data and found the source localization for the resting tremor in the brain using a dipole tracing method. Coherencies between EEG and EMG were also calculated. Significant coherencies were obtained from the electrodes located at Cz, P3 and T3 in the patients who showed a resting tremor in their right hand. Negative EEG potential changes were also obtained from 30msec before until 10msec after the onset of tremor EMG. Source generators during this phase estimated by a dipole tracing method were located in the contralateral thalamus and the cortical hand motor area. The results suggest that the origin of the resting tremor of Parkinson's disease may exist in the oscillatory network of the thalamus and the cortical structure of the hand motor area.
