Association of Lean Mass, Fat Mass, Body Mass Index, and Skinfold Thickness on Bone Mineral Density of Young Japanese Females: An Age-Controlled Cross-Sectional Study

抄録

We examined the potential effects of body size and nutrient status on bone mass in an age-controlled study. Bone mass measured as bone mineral density (total-body: BMD_TB; L2-L4 spine: BMD_L2-4 in g/cm² ), and bone mineral content (total-body: BMC_TB; L2-L4 spine: BMC_L2-4ing), were measured by dual-energy X-ray absorptiometry (DXA) . Body size was evaluated by body mass index [BMI], skinfold thickness [SFT], lean mass [LM], and fat mass [FM] . We recruited 214 young healthy Japanese women living in the same area, who were college students of the same grade (aged 19-21 yr) . In simple correlation analysis, BMD_TB was significantly correlated with LM (r=0.31) and BMI (r=0.23), BMD_L2-4 was significantly correlated with LM (r=0.29) and BMI (r=0.26), and BMC_TB was significantly correlated (p<0.05) with LM (r=0.65), BMI (r=0.39), FM (r=0.32), and SFT (r=0.24) . In addition, BMC_L2.4 was correlated with LM (r=0.47) and BMI (r=0.22) . After adjusting for other body size factors by stepwise multivariate regression analyses, BMI, LM, and FM showed a significant association with BMD_TB and BMD_L2-4, whereas only LM showed significant associations with BMC_TB and BMC_L2-4. Our cross-sectional results suggested that measure of body size might be an important determinant of BMD and BMC in young female adults.