抄録
Changes in coagulation and fibrinolysis were studied in Sprague-Dawley rats with acute diabetes induced by a single intravenous injection of 65 mg/kg or 45 mg/kg of streptozotocin (STZ) . At 2, 24 and 48 hr after 65 mg/kg injection and 144 hr after 45 mg/kg injection, plasma glucose was drastically increased. Suppression of body weight gain and an increase in food and water intake were observed in the 45 mg/kg STZ-treated rats. Plasma lipids increased 24 and 48 hr after 65 mg/kg of STZ treatment, but only triglyceride increased 144 hr after 45 mg/kg injection. Partial thromboplastin time (PTT) was significantly shortened 48 hr after 65 mg/kg and 144 hr after 45 mg/kg. Antithrombin III activity (ATIII) increased significantly 144 hr after 45 mg/kg. Activity of factor XIII decreased 24 hr after 65 mg/kg injection. Neither 6.5 mg/kg nor 45 mg/kg induced changes in the fibrinogen level or fibrinolytic activity. A remarkable increase in plasma glucose was interrelated with shortening of PTT and increased ATIII activity in STZ-treated rats. These results demonstrated enhancement of intrinsic coagulation in rats with acute diabetes induced by STZ.
