Inhaled particle deposition in mammalian lungs

Study by calculational model

Abstract

Depositions of inhaled particles in the lungs of Rat, Hamster and Human were evaluated using calculational deposition models for each species. Calculated results were also examined by a scaling analysis based on the body weight dependence of respiration characteristics and particle behavior in lungs.
Differences were significantly species-dependent for the deposition of larger particles especially at upper airways. While, a slight difference was predicted for the total deposited fraction in the whole lung and for the deposited density at central airways.