Clinically and histologically studies on the gallbladder mucosa with high amylase concentration of bile

Abstract

In cases underwent cholecystectomy, we was measured amylase concentration of the bile and examined clinically and histologically. This study was the object for seven patients with over 1,000 IU/L (high amylase group) and seven patients in less 100 IU/L (control group) in amylase concentration of the bile. In high amylase group, all cases showed maljunction of the pancreatobiliary or a long common channel, and the gallbladder mucosa in the most of those showed papillary type and positive in Ki65LI and MAC5AC. In the high amylase group, the findings on the preoperative US or EUS showed more wall thickness. We suggest that the gallbladder mucosa with high amylase concentration of the bile is high risk of gallbladder cancer and that mucosal thickness of gallbladder on US is important finding.