Two cases of biliary tract carcinoma around the confluence of cystic duct in siblings

Abstract

A 71-year-old woman came to our hospital with abdominal pain. We performed cholecystectomy with a preoperative diagnosis of cholecystitis. A firm nodule at the confluence of cystic duct (CD) was not a stone but a mass. With an intraoperative pathological diagnosis of poorly differentiated adenocarcinoma, extrahepatic bile duct resection with lymphadenectomy was performed. A 73-year-old man, her 14-years younger brother, presented to our hospital with abdominal pain. CT revealed the enhanced tumor spreading from the CD to common bile duct. Pancreaticoduodenectomy was performed. Final pathological diagnosis was papillary adenocarcinoma of the CD. They had no other family history of malignancy and never worked at printing factories. Biliary tract carcinoma in siblings is rare. No specific risk factors of familial neoplastic diseases could not be identified in this particular family.