A resected case of intraductal papillary neoplasm of bile duct (IPNB) developed with invasive ductal adenocarcinoma during follow-up

Abstract

A 78-year-old male who had a liver cystic lesion with 60mm diameters on liver S1 was admitted to our hospital for further examination. At the initial visit, he had no chief complaint, and we observed it as a simple liver cyst for eighteen months. However, it has gradually increased and the solid components with abnormal accumulation on FDG-PET have appeared in cystic lesion. We performed left hepatic trisegmentectomy and extrahepatic bile duct resection based on the diagnosis of hepatic mucinous cystadenocarcinoma. Histopathological examination revealed no obvious ovarian-like stroma. It diagnosed as IPNB with an associated invasive carcinoma. We report a rare case of IPNB which showed the morphological changes during follow up.