2023 Volume 37 Issue 1 Pages 45-54
Background: Mapping biopsy (MB) of the bile duct can help evaluate the pathology of biliary cancer's superficial ductal spread (SDS). However, MB can give false positive or false negative results. Therefore, this study aimed to evaluate the effectiveness of MB.
Method: Thirty-one patients with the perihilar cholangiocarcinoma (PHCC) and 52 with distal bile duct cancer (DBDC) who underwent MDCT, ERC, MB, and surgical resection between 2010 and 2021 were included. The diagnostic ability of image diagnosis (MDCT with ERC) and MB for SDS was evaluated.
Result: The sensitivity and specificity of PHCC were as follows: intrahepatic bile duct side (image diagnosis/MB: 43%/57% [P = 1.0], and 100%/79% [P < 0.05], respectively), distal bile duct side (100%/100% [P = 1.0], and 100%/79% [P < 0.05], respectively). For DBDC (intrahepatic bile duct side), these values were 22%/56% [P = 0.3], and 100%/70% [P < 0.01], respectively. MB is considered to have high sensitivity but significantly low specificity.
Conclusion: We consider that the false-positive identification by MB was caused by tumor contamination during the insertion of biopsy forceps. Therefore, it is necessary to take measures to prevent tumor contamination.
