2026 Volume 40 Issue 1 Pages 100-107
A 76-year-old woman was diagnosed with a gallbladder tumor on plain CT. Contrast-enhanced CT of the abdomen showed thickened wall thickening in the neck of the gallbladder, and enlarged lymph nodes in the vicinity were heterogeneously stained internally, raising suspicion of lymph node metastasis of gallbladder cancer. Bile cytology and EUS-FNA lymph node biopsy showed adenocarcinoma, and the patient was operated on with a diagnosis of gallbladder cancer. The pathological diagnosis was mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN).
Postoperative adjuvant chemotherapy with tegafur/gimeracil/oteracil potassium (S-1) was administered orally. However, recurrence was observed one year after surgery, and chemotherapy according to the standard regimen for biliary tract cancer (gemcitabine plus cisplatin combination therapy) was initiated. Despite this treatment, the disease progressed, and the patient died of the primary disease 36 months after surgery (24 months after recurrence). We report a rare case of primary MiNEN of the gallbladder.
