Immunohistological Investigation of the estrogen receptor in biliary tract cancer and pancreatic cancer.

Abstract

The estrogen receptor (ER) was immunohistologically investigated in biliary tract cancer, pancreatic cancer and benign gall bladder disease with monoclonal antibody. The ER was detected in greatly varying percenages of 90.9% for gallbladder can cer,50% for bile duct cancer,50% for cancer of papilla of Vater,11.1% for pancreatic cancer and 11.1% fornormal gallbladder. Intracellular loalization of the ER was less frequently observed within the nucleus but more commonly observed within the cytoplasm. ER positive cancer did not show any definite tendency in its macroscopic and histological type and infiltrative proliferation mode.