Methyl tert-butyl ether (MTBE)によるコレステロール胆石直接溶解療法の基礎的検討および臨床応用

田妻 進; 佐々木 晴敏; 水野 重樹; 佐用 広; 初鹿 寿美恵; 峠 誠司; 伊藤 正樹; 堀内 至; 松浦 秀夫; 梶山 梧朗; 中井 志郎; 角 重信; 増田 哲彦; 利田 堯史

doi:10.11210/tando1987.4.2_154

A direct dissolution of cholesterol gallstones by methyl tert-buthyl ether

Susumu TAZUMA, Harutoshi SASAKI, Shigeki MIZUNO, Hiroshi SAGAWA, Sumie HATSUSHIKA, Seishi TAO, Masaki ITO, Itaru HORIUCHI, Hideo MATSUURA, Goro KAJIYAMA, Shiro NAKAI, Shigenobu KADO, Tetsuhiko MASUDA, Takashi TOSHITA

Author information

Susumu TAZUMA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Harutoshi SASAKI
The First Department of Internal Medicine, Hiroshima University School of Medicine
Shigeki MIZUNO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Hiroshi SAGAWA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Sumie HATSUSHIKA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Seishi TAO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Masaki ITO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Itaru HORIUCHI
The First Department of Internal Medicine, Hiroshima University School of Medicine
Hideo MATSUURA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Goro KAJIYAMA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Shiro NAKAI
The First Department of Internal Medicine, Hiroshima University School of Medicine
Shigenobu KADO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Tetsuhiko MASUDA
Department of Surgery, Hiroshima Memorial Hospital
Takashi TOSHITA
Toshita Veterinary Hospital

Keywords: methy1 tert-buty1 ether(MTBE)

JOURNAL FREE ACCESS

1990 Volume 4 Issue 2 Pages 154-161

DOI https://doi.org/10.11210/tando1987.4.2_154

Details

Abstract

We studied on the safety of methy1 tert-buthyl ether (MTBE) infusion into the gallbladder in mongrel dogs.
Results w ere as follows; During the MTBE infusion,
1) no remarkable change was found in the c i rculatory system,
2) the serum level of MTBE did not exceed 100 ppm. After 3 hours' infusion of MTBE,
3) no histological evi d ence of the canine gallbladder damage was found by either light microscopy or scanning electron microscopy.
On basis of our experiments i n dogs, we treated 3 patients with radiolucent gallstones with MTBE, to successfully dissolve those stones in 3-12 hours.In addition, no recurrence of gallstones has been detected by ultrasonography for at least 1 year.
In conclusion, MTBE has encouraging potential as a safe and highly effective gallstone dissolution solvent.

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