31 麦赤カビ病菌Fusarium nivale代謝有毒成分の中毒学的検討(第6報) : Nivalenol及びその関連化合物の化学構造に関する研究

抄録

Red mold wheat caused Fusarium species has been well known as a disease of wheat, barley, oat or rye in many regions. Recently, several kinds of Fusarium sp. were collected from damaged wheat and examined for toxicity. F. nivale (Fn-2) was selected as the isolation of toxic agents, and principle toxins, nivalenol (I), fusarenon-X (II) and nivalenol diacetate (III) were isolated from the charcol-absorbable materials of the F. nivale-growing rice and the cultured filtrate. Pathological examination proved that the fungi-growing rice and these toxins gave necrosis and degeneration of the intestine, bone marrow, lvmp node, thymus and testis of mice, indicating that dividing cells of these tissues were actively injured so called radio-mimetic affections. By the chemical and spectroscopic interconnection with diacetoxy-scirpenol (VI) which has been isolated from the plant parasitic fungus, Fusarium sp. by P. W. Brian and other chemists, the chemical structures of nivalenol, fusarenon-X and nivalenol diacetate was proposed as (I), (II) and (III) respectively. From the mass spectrometrical investigations of these compounds, we tried to confirm the acetylated position of these compounds in addition to chemical and spectroscopic data. Finding the fragment ion peaks which are common to the mass spectra of these compounds, tetrahydroscirpenone and its acetate, we presumed the process of the degradations. We should like to develop this result to a new approach for detection of small amount of these materials which will be contaminated in the cereals.