25 プロスタグランディンF_<1α>の立体特異的全合成

抄録

We report a new highly stereospecific total synthesis of PGF_<1α> (1), which proceeds in good to excellent yield at each step. Four asymmetric centers on the cyclopentane ring required for the synthesis of PGF_<1α> was introduced stereospecifically by the catalytic reduction of the enone (6) with palladium on charcoal (6→7: the formation of three asymmetric centers), followec by sodium borohydride reduction (7→8: the formation of additional one asymmetric center).