6 グラヤノトキシン類の合成研究

抄録

The syntheses of compound 1, grayanol A and B have been attempted, and the following experiments were carried out. The compound 3 was converted into the cleaved product 19 containing a ten-membered ring system through the route shown in Chart I. The compound 19 was cyclized into compound 21. The compound 4, the C-9 epimer of 5, was transformed into cyclodecanone 32 through the passway via 22 to 31, but an attempted isomerization of the double bond was not successful. The CD ring system of grayanols was synthesized through the sequence shown in Chart III. The cyclodecanone system which corresponded to that of 1-deoxygrayanol was synthesized starting from compound 34 by the route shown in Chart IV. The investigations for the final synthetic steps are in progress.