抄録
Two ionophor-like active principles, hypelcin A and B were isolated from fruit bodies of Hypoclea peltata which prevents the growth of Lentinus edodes, 'Shiitake'. Hypelcins were shown to be a linear polypeptide with 19 amino acid residues containing 10 α-aminoisobutyric acid residues. The N-terminus, α-aminoisobutyric acid, of hypelcin A is blocked by an acetyl group, and the nineteenth residue, glutamine, is linked by an amide bond to leucinol. The structure (8) of hypelcin A was proposed by a comparison between hypelcin A and the products of partial hydrolysis. The difference between hypelcin A and B lies in the replacement of one of the three glutamine units of hypelcin A by a mole of glutamic acid unit in hypelcin B. Hypelcins increased the respiration rate of mitochondria in the presence of succinate as substrate and inorganic phosphate. The stimulated respiration was enhanced on addition of KCl. The effects could be related to the alamethicin-like action on mitochondrial function.
