26 パラオ海域の海綿から得られたアルドース還元酵素阻害物質

抄録

Large number of pharmacologically active natural products have been isolated from the marine organisms. Since 1981, we have carrying out the investigation of pharmacologically active compounds from marine organisms forcusing on sponges which collected in southern Pacific water such as Australia, Okinawa and Palau. We isolated many pharmacologically active compounds from the marine invertebrates. In this paper we have tested aldose reductase inhibitor assay to about 100 species of Palauan sponges. Aldose reductase inhibitor is one of the most important therapeutical use for galactsemic cataract. Extracts of the sea sponges Dysidea sp., Ircinia ramosa and Dactylospongia metachromia showed aldose reductase inhibitory activities at the concentration of 400μg/ml. Active principles were polybromo phenol(1), palinurin(2) and sesterterpene lactone(4) respectively. We isolated the aldose reductase inhibitory active new sesterterpenoidal acid(5) from the other Dysidea sp. which structure was elucidated by spectroscopic method.