抄録
In order to synthesize useful materials, we examined biotransformation of acetophenone, xanthone, chromanone and their analogs by fungi (Botrytis cinerea) or cultured cells of beans (Glycine max) and apple (Malus pumila Vonagold'). We found out that G max (or M pumila) cells were not active for the reduction of xanthone into xanthydrol (or acetophenone into 1-phenylethanol), but active for the oxidation of xanthydrol into xanthone (1-phenylethanol into acetophenone). We confirmed that the reaction (oxidation) progressed quickly by NADP (or NADPH) addition as coenzyme. However, we found that B. cinerea cells were not active for the oxidation of xanthydrol to xanthone, but active for the reduction of xanthone to xanthydrol. Therefore, we think that redox control is possible by using callus and fungi properly. This fact is very interesting from a viewpoint of synthetic application.
