Biological Activity of the Polysaccharide Produced by the Marine Phytoplankton Porphyridium sp. and Additive Effect of Slag on the Polysaccharide Production

Hiroko SAKAMOTO; Hideyuki TORADA; Kentaro GOTO; Yasue NAKAMURA; Toshiki NAKANO; Toshiyasu YAMAGUCHI; Minoru SATO; Tadao SAITO; Akira TANIGUCHI; Takehiko YOKOYAMA; Nobuhiro KAN-NO; Eizou NAGAHISA

doi:10.2355/tetsutohagane1955.89.4_475

Biological Activity of the Polysaccharide Produced by the Marine Phytoplankton Porphyridium sp. and Additive Effect of Slag on the Polysaccharide Production

Hiroko SAKAMOTO, Hideyuki TORADA, Kentaro GOTO, Yasue NAKAMURA, Toshiki NAKANO, Toshiyasu YAMAGUCHI, Minoru SATO, Tadao SAITO, Akira TANIGUCHI, Takehiko YOKOYAMA, Nobuhiro KAN-NO, Eizou NAGAHISA

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Keywords: polysaccharide, phytoplankton, biological activity, mitogen, antitumor, slag, Porphyridium sp.

JOURNAL OPEN ACCESS

2003 Volume 89 Issue 4 Pages 475-481

DOI https://doi.org/10.2355/tetsutohagane1955.89.4_475

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Abstract

Marine phytoplankton Porphyridium sp. produced and secreted a mucilaginous polysaccharide in the incubation medium. The polysaccharide production was enhanced by the addition of slag at proper concentration. This polysaccharide showed a moderate mitogen activity, similar to dextran sulfate but lower than concanavalin A and lipopolysaccharide. Polysaccharide was found to have antitumor activity against Sarcoma 180 inoculated in the peritoneal cavity of ddY mice.

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