Thermal Medicine
Online ISSN : 1882-3750
Print ISSN : 1882-2576
ISSN-L : 1882-2576
Original Paper
Mode of Tumor Necrosis Induction in vivo by Heat-generating Nanoparticles of Magnetite Cationic Lipid Composite Particles Dispersing toward Neighbor Naïve Tumor Zone and its Therapeutic Use
TOMIO MORINOHIROSHI TAKASENORIYASU KAWAITAKASHI NAGAITOSHIKI ETANITAKU NAIKITAKAHIRO YASUI
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2022 Volume 38 Issue 1 Pages 19-26

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Abstract

Magnetite cationic lipid composite particles (MCL particles, formerly named magnetite cationic liposomes) injected in tumor tissue has been shown to expand tumor necrosis area stepwisely by multiple alternating magnetic field (AMF) irradiations which triggered heat generation of MCL particles. This study investigated mode of tumor necrosis induction and process of MCL particles dispersion in vivo in order to verify therapeutic protocol.

Tumor necrosis area induced by the 1st AMF irradiation showed amoeba-like shape with clear outline owing to area where MCL particles distributed. During 24 hours after the irradiation, almost all MCL particles disappeared from the necrosis area, and dispersed to neighbor naïve tumor zone and accumulated in interstitial spaces of alive tumor cells. Structural change of dispersed MCL particles was not observed in situ by electron microscopy. The data verified necessity of time intervals between AMF irradiations for particle dispersion and reusage of MCL particles in following multiple AMF irradiations. Dispersion and infiltration of MCL particles toward surrounding normal tissue were not observed and its mechanism was shortly discussed together with driving forces of the particle dispersion in vivo.

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