Thermal Medicine
Online ISSN : 1882-3750
Print ISSN : 1882-2576
ISSN-L : 1882-2576
Current issue
Displaying 1-2 of 2 articles from this issue
    2022 Volume 38 Issue 2 Pages 33-50
    Published: July 01, 2022
    Released on J-STAGE: August 08, 2022

    The p53 tumor suppressor is frequently mutated in various types of cancer. Majority of p53 mutations are missense mutations, which results in not only loss of the tumor suppressive activity (loss of function), but also acquirement of unexpected oncogenic activities, referred to as gain of function (GOF). Although the stability and accumulation of wild-type p53 (wtp53) and mutant p53 (mutp53) proteins are crucial to exhibit the tumor suppressive and oncogenic activities, respectively, the underlying mechanisms remain unclear. Heat shock proteins (HSPs) are one of the major molecular chaperones which have a variety of functions including protein folding, transportation, and stabilization and degradation of misfolded or denatured proteins. Of the HSP family, HSP40, also known as J-domain proteins (JDPs), is the largest family with over fifty members and contains the highly conserved J domain. HSP40/JDPs mainly function as a co-chaperone of HSP70 to stimulate the ATPase activity through interactions between the J domain of HSP40/JDPs and HSP70. Increasing evidence indicates HSP40/JDPs also regulate levels and activities of wtp53 and mutp53. Here, we introduce our recent studies regarding the roles of DNAJA1 in accumulation of misfolded or conformational mutp53 and cancer metastasis, and also summarize updated information related to the regulation of tumor suppressive wtp53 and oncogenic mutp53 activities by HSP40/JDPs.

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Original Paper
    2022 Volume 38 Issue 2 Pages 51-61
    Published: July 01, 2022
    Released on J-STAGE: August 08, 2022

      This paper describes the heating characteristics of a small rectangular resonant cavity applicator heating system with a non-invasive ultrasound temperature measurement system. In a previous study, the authors developed a small rectangular resonant cavity applicator for deep part of the knee joint hyperthermia.

      In this study, in order to ensure the safety of this applicator and improve treatment effect, we have developed a hyperthermia treatment system with a non-invasive temperature measurement system. In order to show the usefulness of the developed system, we conducted heating and temperature measurement experiments using a human leg-shaped agar phantom with simulated bones. From the results of this experiment, the error from the measured temperature results is about 0.3 ℃. And this prototype system can be used for clinical application without causing abnormal heating around the bones and at the target site in the joint cavity. It was clarified experimentally that there is a possibility of effective warming treatment.

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